Initiation of Insulin Treatment in Type 2 Diabetes Mellitus

Initiation of Insulin Treatment in Type 2 Diabetes Mellitus

European Endocrine Disease 2007 - Issue I
Published: October 2008
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Type 2 diabetes mellitus (T2DM) is a frequently occurring disease and its incidence and prevalence is expected to increase considerably all over the world. T2DM is an important disease because of the frequent complications (micro- and macrovascular) that may occur after several years, resulting in reduced life expectancy, as well as miserable quality of life and an increasing economic burden.

However, prevention of high blood glucose (BG) and maintenance of glycated haemoglobin A1C <7.0% have been demonstrated to reduce the incidence of all complications of T2DM. Therefore, it is essential that T2DM is not only prevented (i.e. by tackling obesity and implementing an active lifestyle), but is also diagnosed early and treated aggressively from its initial phase to prevent the onset of complications.


Unfortunately, risk factors for T2DM such as obesity are often not treated. In addition, T2DM itself is often undiagnosed and, when diagnosed, remains – in the majority of cases – undertreated with fasting and post-prandial BG, as well as A1C, all above the recommended targets. No surprise, then, that under these conditions T2DM continues to be a major problem for affected patients.


Among other reasons (poor diet and lack of physical exercise), one factor of poor BG control in T2DM is the late use of insulin. Doctors claim that it is the T2DM patients who do not accept insulin treatment, but in reality it is the doctors who do not have the culture of ‘early insulinisation’ and its commensurate benefits and advantages to improve prognosis of the disease. The modern concept of early insulinisation with once-daily administration of basal insulin may improve compliance of doctors and patients and play a major role in reducing A1C in the T2DM population.

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