Laparoscopic Radical Hysterectomy for Early-stage Cervical Cancer

Laparoscopic Radical Hysterectomy for Early-stage Cervical Cancer

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While gynecologists have used laparoscopy for nearly 50 years, it was not until the 1990s that laparoscopy gained acceptance among gynecological oncologists for advanced procedures such as hysterectomy with lymphadenectomy for endometrial cancer. More recently, total laparoscopic radical hysterectomy (TLRH) for early-stage cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] stages IA2 and IB1) has proved both safe and feasible. First described in the early 1990s,1,2 growing evidence supports its benefits and possibly even superiority over laparotomy in radical hysterectomy.

While technically challenging with a steep learning curve, clear advantages include decreased operating time, lower patient morbidity, shorter length of inpatient hospitalization, less blood loss, improved cosmesis, and comparable outcomes to laparotomy, including recurrence rates and lymph- node yield. Newer robotic technology alleviates some of the shortcomings of laparoscopy, and robot-assisted radical hysterectomy (RRH) may soon surpass TLRH as a minimally invasive procedure.

Total Laparoscopic Radical Hysterectomy

Both patients and physicians have driven the advancement of minimally invasive surgery. The pursuit of cutting-edge technology by physicians and academic institutions has promoted the expansion of minimally invasive techniques, and training opportunities abound. With increasing public awareness, many patients are now requesting minimally invasive surgery. Patients with early-stage, IA2, or IB1 cervical cancer are traditionally offered an abdominal radical hysterectomy and pelvic lymphadenectomy. First described by Canis et al.1 and Nezhat et al,2 TLRH for early-stage cervical cancer has been proved efficacious and safe by a number of other groups3–9 and is gaining popularity. The best candidates for TLRH include those with early-stage disease (IA2 or IB1), tumor size <4cm, and uterine size <12cm. Patients with a bulky uterus or bulky cervical tumors, severe hip or joint disease, or intraperitoneal metastases are generally not suitable candidates for the procedure.

Total Laparoscopic Radical Hysterectomy Technique

Informed consent is obtained. All patients undergo pre-operative bowel preparation and receive prophylactic antibiotics. After placement in lithotomy position with arms tucked at the sides, a Foley catheter is inserted. A uterine manipulator is placed. The patient is placed in steep Trendelenburg position. Based on surgeon preference of endoscope size, a 5, 10, or 12mm bladeless trocar is situated at the umbilicus under direct visualization of the abdominal cavity. If the patient has a prior mid-line incision, entry can be made at Palmer’s point 2cm below the left costal margin in the mid-clavicular line. The abdomen is insufflated, and three additional bladeless trocars (5, 10, or 12mm) are placed in the right lower quadrant, left lower quadrant, and the mid-line 2cm above the pubic symphysis. At least one of the three trocars must measure 10 or 12mm in order to permit lymphadenectomy. An abdominal survey is then performed to rule out intraperitoneal disease. The bowel is mobilized out of the surgical field.

Table 1: Outcomes for Laparoscopic Radical Hysterectomy

OR = operating room; LOS = length of stay; EBL = estimated blood loss; NR = not reported. § This study included patients with IIIa and IIIb disease as well.

The round ligaments are then transected bilaterally. The peritoneum is incised over the psoas muscle immediately lateral to the infundibulopelvic ligament, and the ureters are identified. Any suspicious-appearing lymph nodes are then removed and sent for frozen pathology, as the procedure is aborted in the presence of metastatic disease. Next, the paravesical and pararectal spaces are identified and exposed. The uterine vessels are identified and transected at the point of origin from the iliac vessels. The bladder is then mobilized inferiorly. The ureters are freed from their medial attachments to the peritoneum, and then dissected off the parametrium down to their insertion into the bladder. The vesicouterine ligament is divided at its lateral aspect, and the bladder further mobilized so as to provide ample vaginal margins.

References:
  1. Canis M, Mage G, Wattiez A, et al., Does endoscopic surgery have a role in radical surgery of cancer of the cervix uteri?, J Gynecol Obstet Biol Reprod (Paris), 1990;19:921.
  2. Nezhat CR, Burrell MO, Nezhat FR, et al., Laparoscopic radical hysterectomy with paraaortic and pelvic node dissection, Am J Obstet Gynecol, 1992;166:864–5.
  3. Frumovitz M, does Reis R, Sun CC, et al., Comparison of total laparoscopic and abdominal radical hysterectomy for patients with early-stage cervical cancer, Obstet Gynecol, 2007;110:96–102.
  4. Spirtos NM, Eisenkop SM, Schlaerth JB, et al., Laparoscopic radical hysterectomy (type III) with aortic and pelvic lymphadenectomy in patients with stage I cervical cancer: Surgical morbidity and intermediate follow-up, Am J Obstet Gynecol, 2002;187:340–48.
  5. Chen Y, Xu H, Li Y, et al., The outsome of laparoscopic radical hysterectomy and lymphadenectomy for cervical cancer: A prospective analysis of 295 patients, Ann Surg Oncol, 2008; 15:2847–55.
  6. Ramirez P, Slomovitz BM, Soliman PT, et al., Total laparoscopic radical hysterectomy and lymphadenectomy: the M. D. Anderson Cancer Center experience, Gynecol Oncol, 2006;102:252–5.
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  9. Li G, Yan X, Shang H, et al., A comparison of laparoscopic radical hysterectomy and pelvic lymphadenectomy and laparotomy in the treatment of Ib-IIa cervical cancer, Gynecol Oncol, 2007;105: 176–80.
  10. Sert BM, Abeler VM, Robotic-assisted laparoscopic radical hysterectomy in early-stage cervical carcinoma patients, comparing results with total laparoscopic radical hysterectomy cases. The future is now?, Int J Med Robot, 2007;3:224–8.
  11. Nezhat FR, Datta MS, Liu C, et al., Robotic radical hysterectomy versus total laparoscopic radical hysterectomy with pelvic lymphadenectomy for treatment of early cervical cancer, JSLS, 2008;11:227–37.
  12. Magrina JF, Goodrich MA, Weaver AL, et al., Modified radical hysterectomy: morbidity and mortality, Gynecol Oncol, 1995;59: 277–82.
  13. Kim YT, Kim SW, Hyung WJ, et al., Robotic radical hysterectomy with pelvic lymphadenectomy for cervical carcinoma: a pilot study, Gynecol Oncol, 2008;108:312–16.
  14. Fanning J, Fenton B, Purohit M, Robotic radical hysterectomy, Am J Obstet Gynecol, 2008;198:649e1–e4.
  15. Obermair A, Gebski V, Frumovitz M, et al., A phase III randomized controlled trial comparing laparoscopic or robotic radical hysterectomy with abdominal radical hysterectomy in patients with early stage cervical cancer, J Min Inv Gyn, 2008;15:584–8.

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