The management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report
The management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report
Published: February 2010
Abstract
Introduction
Hypercalcaemic hyperparathyroid crisis is a rare but life-threatening complication of primary hyperparathyroidism. Parathyroid carcinoma is a rare malignancy with an incidence of 0.5% to 4% of all reported cases of primary hyperparathyroidism.
Case presentation
We report the case of a 60-year-old Caucasian man with hypercalcaemic hyperparathyroid crisis associated with parathyroid carcinoma. He presented with a classic hypercalcaemic syndrome and his serum calcium and parathyroid hormone levels were at 4.65mmol/L and 1743ng/L, respectively. He initially presented with a two-week history of weakness and lethargy and a one-week history of vomiting, polyuria and polydipsia. An emergency left thyroid lobectomy and left lower parathyroidectomy were performed. There was a prompt decrease in his parathyroid hormone level immediately after surgery. Histology revealed that our patient had a 4- cm parathyroid carcinoma.
Conclusion
In patients with parathyroid carcinoma, the optimal surgical treatment is en bloc resection with ipsilateral thyroid lobectomy and removal of any enlarged or abnormal lymph nodes. Surgery is the only curative treatment. In our patient, prompt surgical intervention proved successful. At six months the patient is well with no evidence of disease recurrence. This case highlights the importance of considering a hyperparathyroid storm in the context of a parathyroid carcinoma. Parathyroid carcinoma is a rare entity and our knowledge is mainly derived from case reports and retrospective studies. This case report increases awareness of this serious and life threatening complication. This report also illustrates how prompt and appropriate management provides the best outcome for the patient.
Introduction
Hypercalcaemic hyperparathyroid crisis is a rare but life-threatening complication of primary hyperparathyroidism. The symptoms of hypercalcaemia are frequently nonspecific and reflect multi-organ involvement. This condition should be suspected in acutely ill patients with profound dehydration, gastrointestinal manifestations, urinary symptoms, altered mental state, or cardiac arrhythmias. Parathyroid carcinoma is a rare malignancy with an incidence of 0.5% to 4% of reported cases of primary hyperparathyroidism [1,2].
In patients with parathyroid carcinoma, the optimal surgical reatment is en bloc resection with ipsilateral thyroid lobectomy and the removal of any enlarged or abnormal lymph nodes [3]. Surgery is the only curative treatment. The cure rate is reported as being as high as 98% [4].
- Levin KE, Galante M, Clark OH: Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcaemia. Surg 1987, 101:649- 660.
- Shortell CK, Andrus CH, Philips CE Jr, Schwartz SI: Carcinoma of the parathyroid gland: a 30-year experience. Surg 1991, 110:704-708.
- Sheehan JJ, Hill AD, Walsh MF, Crotty TB, McDermott EW, O’Higgins NJ: Parathyroid carcinoma: diagnosis and management. Eur J Surg Oncol 2001, 27:321-324.
- Udelsman R: Six hundred and fifty-six consecutive explorations for primary hyperparathyroidism. Ann Surg 2002, 235:665-670.
- Levin K, Galante M, Clark O: Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcaemia. Surg 1987, 101:647- 660. 6. Schoretsanitis G, Daskalakis M, Melissas J, Tsifsis D. Parathyroid carcinoma: clinical presentation and management. Am Journ of Otolaryngol – Head and Neck Med and Surg 2009, 30:277-280.
- Rodgers SE, Hunter GJ, Hamberg LM, Schellingerhout D, Doherty DB, Ayers GD, Shapiro SE, Edeiken BS, Truong MT, Evans DB, Lee JE, Perrier ND: Improved preoperative planning for directed parathyroidectomy with four-dimensional computed tomography. Surg 2006, 140(6):932-940.
- Udelsman R: Six hundred and fifty-six consecutive explorations for primary hyperparathyroidism. Ann Surg 2002, 235:665–670.
- Sheehan JJ, Hill AD, Walsh MF, Crotty TB, McDermott EW, O’Higgins NJ: Parathyroid carcinoma: diagnosis and management. Eur J Surg Oncol 2001, 27:321-324.
- Shane E: Parathyoid carcinoma. J Clin Endocrinol Metab 2001, 86:485-493.
- Sandelin K, Thompson NW, Bondeson L: Metastatic parathyroid carcinoma: dilemmas in management. Surgery 1991, 110:978-988.
- Clayman GL, Gonzales HE, El Naggar A, Vassilopoulou R: Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer 2004, 100:900-905.
- Obara T, Fujimoto Y: Diagnosis and treatment of patients with parathyroid carcimona: an update and review. World J Surg. 15:738-744.
- Hundahl SA, Fleming ID, Fremgen AM, Menck HR: Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985 and 1995: a National Cancer Database Report. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1999. 86:538-544.






