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Welcome to the latest edition of touchREVIEWS in Endocrinology, which features a range of review, case report and original research articles that highlight some key developments in our understanding and management of endocrinological disease. We begin with a commentary from Eleni Armeni and Ashley Grossman on seliciclib, a potential new treatment for patients with Cushing’s […]

Gestational diabetes mellitus (GDM) is generally defined as “any degree of glucose tolerance with onset or first recognition during pregnancy”.1 It currently is one of the diseases with the highest morbidity among pregnant women.2 Determining its prevalence has been a real challenge for the scientific community due to multiple modifications in the diagnostic criteria established in 1964 […]

Periodontitis is a chronic inflammatory disease of the periodontium, or the supportive tissues around the tooth, which includes the gingival tissue, alveolar bone, cementum and the periodontal ligament.1 Caused by pathogenic bacteria, this disease has been recognized for at least 5,000 years and has been related to diverse risk factors, such as the presence of plaque […]

Obesity is related to an increased risk of metabolic disease.1 It is well established that excessive body fat is related to increased morbidity and mortality and is associated with inflammation and endothelial damage.2,3 With age, fat infiltration occurs in the muscle, leading to sarcopenia. The association of the excessive accumulation of adipose tissue with a progressive decrease […]

Non-alcoholic fatty liver disease (NAFLD) consists of non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). It is unclear which specific patients progress from NAFL to NASH and, ultimately, to cirrhosis. However, there is general consensus that, for those patients who do progress to cirrhosis (fibrosis stage 4), there is an increased risk of liver-related complications […]

Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome, considered the most common endocrinopathy in women of reproductive age, with a prevalence of 6–8% in premenopausal women.1,2 However, long-term sequelae are extended beyond the reproductive axis, being present from birth to senescence. Consequently, early detection and treatment options are in high demand to prevent long-term complications. This […]

Obesity is now a major public health issue with an increasing prevalence worldwide.1 Obesity is also closely linked to increased morbidity and mortality caused by the complications related to obesity, such as type II diabetes, atherosclerosis, hypertension, infertility, neurodegenerative diseases, and even cancers.2,3 Obesity is the deposition of excess fat in the body caused by […]

The global prevalence of obesity has increased tremendously in recent years. According to the World Health Organization, 39% of adults were overweight, of which 13% were obese, in 2016.1 The association between excess body weight and several medical conditions that increase morbidity and mortality is well-known. Recent clinical evidence suggests that obesity is one of the […]