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Dipeptidyl Peptidase-4 Inhibitors and the Management of Hyperglycemia
consumption. These favorable characteristics may help clinicians and
patients overcome clinical inertia, thereby facilitating therapy Pamela M Katz, MD, is a Resident in the Division of
intensification and achievement of recommended glycemic targets.
Endocrinology and Metabolism at the University of Toronto.
Her clinical interests include treatment of type 2 diabetes,
Another encouraging feature is their potential disease-modifying effects,
hyperlipidemia, and endocrine disorders in pregnancy.
including preservation of pancreatic beta-cell mass and enhancement of Her research interests include quality improvement in
beta-cell function.
the management of dyslipidemia and iodine nutrition
in pregnancy.
Overall, these medications appear safe and well tolerated. However, the
durability of their effects and the long-term safety profile of these agents
Lawrence A Leiter, MD, is Head of the Division of
Endocrinology and Metabolism at St Michael’s Hospital in
remain to be established. In addition, data are as yet lacking for
Toronto and a Professor in the Departments of Medicine
important patient-centered outcomes such as diabetes complications, and Nutritional Sciences at the University of Toronto.
cost of therapy, and health-related quality of life, although long-term
His research interests include clinical trials on the
prevention of atherosclerosis, especially in diabetes, and
outcome studies are being initiated.
102
Further studies and clinical
the dietary and pharmacological treatment of diabetes,
experience will help to clarify the precise role that DPP-4 inhibitors will hyperlipidemia, hypertension, and obesity.
play in the management of type 2 diabetes. n
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US ENDOCRINOLOGY 69
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