touchEXPERT BRIEFING

Updates and new guidelines in statin therapy

Clinical specialists from Europe and the USA discuss the management of cholesterol in patients with high low-density lipoprotein cholesterol (LDL-C). The importance of using a high dose of a statin is emphasized especially in patients at high risk.

The information in this activity is intended for healthcare professionals involved in the treatment of patients with high LDL-C levels.

This EXPERT BRIEFING was recorded during the ESC Congress 2019, Paris, France.

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Learning Objectives

After watching this touchEXPERT BRIEFING, you should be able to:

  • Understand the importance of the ACC/AHA 2018 and ESC 2019 guidelines for management of blood cholesterol/dyslipidaemias with respect to clinical practice
  • Know the risks and benefits of statin treatment with respect to the risk for type 2 diabetes
  • Understand the potential for abnormal liver function and metabolic syndrome and be aware of drug-drug interaction as most statins are metabolized via the cytochrome P450 pathway
  • Know that the PROVE IT and REAL-CAD trials show that high-dose statin therapy is superior to moderate or low dose in cardiovascular event reduction
  • Understand that combination therapy gives an additional reduction in LDL levels and that statin dose should be titrated to risk

References

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  17. Mach F, et al. Eur Heart J 2020;41:111-88.
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  19. Taguchi I, et al. Circulation 2018;137:1997-2009.
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  22. Boekholt SM, et al. J Am Coll Cardiol 2014;64:485-94.
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  24. Schwartz GC, et al. NEJM 2018;379:2097-2107.

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