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Thyroid gland inside human body. 3D illustration
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Thyroid eye disease (TED), also known as Graves’ orbitopathy, is a complex autoimmune disorder driven by an interplay of immune cells, orbital fibroblasts and tissue remodelling factors that lead to inflammation, oedema and, ultimately, potential vision loss.1 While the disease has historically been challenging to manage, recent therapeutic innovations are reshaping treatment paradigms and offering new […]

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The pioneering work carried out by the French scientist Alfred Jost in the mid-20th century clearly showed that, in the mammalian foetus, the internal and external genitalia virilize whenever the undifferentiated gonads develop into testes, whereas they undergo the ...

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Lucas Ribeiro dos Santos, Erico Paulo Heilbrun, Charles Simões Félix

Congenital adrenal hyperplasia is an innate error in the biosynthesis of adrenal steroids, which triggers a wide range of consequences based on the level of the enzyme blockade. A deficiency in the enzyme 21-α-hydroxylase is the most frequent cause, ...

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