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Showing Results for chronic renal insufficiency
Olaf Dekkers highlights this new European Society of Endocrinology and Endocrine Society Joint Clinical Guideline,1 the first of many future collaborations
Amyloid goiter (AG) is a benign condition characterized by the deposition of amorphous proteinaceous material in the thyroid gland to an extent that results in detectable enlargement during clinical evaluation.1–3 Amyloid can infiltrate the thyroid gland in 15–50% of individuals with ...
Obesity defined as abnormal or excessive fat accumulation that presents a risk to health, is a chronic disease linked to metabolic co-morbidities, such as type 2 diabetes mellitus and cardiovascular disease, a reduced life expectancy, economic burden and reduced quality of ...
Osilodrostat, a novel potent oral steroidogenesis inhibitor, has recently been approved for the treatment of adult patients with endogenous Cushing’s syndrome (CS), and Cushing’s disease (CD) not cured by pituitary surgery or in whom pituitary surgery is not ...
Thyrotoxicosis refers to the signs and symptoms derived from excess circulating thyroid hormones in the body,1Â which must be differentiated from hyperthyroidism, in which there is an increase in the synthesis and secretion of hormones by the thyroid gland.2Â Approximately 1% ...
Short stature affects 2.5% of children and is one of the most common reasons for consulting a growth specialist during childhood.1Â Normal height is a polygenic trait and derives from the interaction of several factors. It is known that height is ...
Congenital adrenal hyperplasia is an innate error in the biosynthesis of adrenal steroids, which triggers a wide range of consequences based on the level of the enzyme blockade. A deficiency in the enzyme 21-α-hydroxylase is the most frequent cause, ...
Renal tubular acidosis (RTA) is characterized by the impaired ability of the kidneys to absorb filtered bicarbonate or to excrete titrable acid in urine.1Â It manifests as normal anion gap (hyperchloremic) metabolic acidosis. RTA may be of four types: type 1 (...
Immune checkpoints are small molecules that are present on the cell surface of T lymphocytes to regulate the immune response. While some of these molecules enhance the stimulatory signals, others boost the inhibitory signals to blunt the activity of T ...
World Health Organization statistics rank tuberculosis (TB) amongst the top 10 communicable diseases in the world, and it remains one of the biggest killers of mankind.1Â TB is known to cause both mortality and morbidity. Pulmonary TB is the primary manifestation, ...
Tuberculosis (TB) is a major public health concern in low- and middle-income countries (LMICs) of Asia and Africa, which have a high burden of human immunodeficiency virus (HIV) infection and malnutrition. It is epidemic in these regions being associated with ...
The use of immunotherapy in the treatment of cancer has been revolutionary, opening a new era in the fight against cancer. The principle of immunotherapy involves using pharmacotherapy to harness the power of the body’s own immune system to ...
Adrenocortical carcinoma (ACC) is a rare malignancy, and presentation as bilateral adrenal masses and acute adrenal insufficiency is even rarer. Due to the relative commonality of other causes for bilateral adrenal masses, such as metastases or infiltrative diseases, they take ...
Recent advances have bolstered the anticancer therapeutic armamentarium. However, despite the enhanced efficacy and better survival offered by these newer agents, side effects remain a source of concern.1Â Gastrointestinal side effects, organ toxicities and dyselectrolytaemias are critical adverse consequences. Among ...
Sanjay Kalra,1 Atul Kalhan,2Â Zhanay A Akanov3 Department of Endocrinology, Bharti Hospital, Karnal, India Department of Endocrinology, Royal Glamorgan Hospital, Cardiff, UK Kazakh Society for Study of Diabetes, Kazakhstan The coronavirus (COVID-19) pandemic has impacted human life in many ...
Growth hormone deficiency (GHD) is an endocrine cause of short stature. GHD may be idiopathic, due to brain tumours affecting the pituitary gland, morphologic pituitary abnormalities, or genetic defects.1,2 The diagnosis of GHD is based on auxologic criteria and laboratory ...
Hyperinsulinaemic Hypoglycaemia (HH) is a very rare disease with an estimated incidence of 1/50,000,1 and includes a clinical, histological and genetic heterogeneous group of disorders characterised by hypoglycaemia, hyperinsulinism or, more specifically, increased C-peptide level and inappropriate low blood levels of ...
Muslims represent 18–25% of the global population, which is approximately 1.1–1.5 billion people.1 There are about 50 million Muslims worldwide with diabetes who fast during the holy month of Ramadan each year.2 All healthy Muslims aged from late childhood or early adolescence or ...
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