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Article highlights Epigenetics refers to the heritable changes in DNA expression without changes in the genetic code. Epigenetic changes are brought about by post-translational modifications of histone proteins, covalent modifications of DNA bases and microRNA. Epigenetics explains how environmental milieu such as diet, physical activity, circadian rhythm, intrauterine malnutrition or maternal obesity interact with the genome of […]

Clinical Complexity of Type 2 Diabetes

Clinical Complexity of Type 2 Diabetes

Pituitary Adenomas

Pituitary Adenomas

The ACMG is the only nationally recognized interdisciplinary professional membership organization that represents the interests of the entire medical genetics team including clinical geneticists, clinical laboratory geneticists, and genetic counselors. Together, the ACMG and its members engage in coordinated efforts to improve patient care, ensure optimal reimbursement for genetic service providers, establish standards of care […]

Improved understanding of the aetiology and pathogenesis of these complications is urgently needed. Effective screening strategies to identify individuals with diabetes most likely to develop complications could improve outcomes by focusing resources on those at highest risk. What Is Diabetic Nephropathy?

Type 1 diabetes has become one of the most studied polygenic disorders. It effects over 1.4 million people in the US, with a rising incidence in many western nations.1,2 It is clear that there is a strong hereditary component in the development of disease, with siblings at higher risk than offspring and both at higher […]