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Inflammation, Oxidative Stress, and the Metabolic Syndrome

Published Online: June 6th 2011 US Endocrinology, 2008;4(2):32-7 DOI: http://doi.org/10.17925/USE.2008.04.2.32
Authors: Ishwarlal Jialal, Rajeev Goyal, Sridevi Devaraj
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Overview

Metabolic Syndrome
The metabolic syndrome (MetS) comprises a cluster of metabolic abnormalities with insulin resistance and adiposity as its central features, which confer an increased propensity to diabetes and cardiovascular disease (CVD). The metabolic abnormalities include central obesity, dyslipidemia (high triglycerides, low high-density lipoprotein [HDL]), hypertension, and impaired fasting glucose (IFG). Five diagnostic criteria have been identified by the Adult Treatment Panel III (ATP-III) and the presence of any three features (central obesity, dyslipidemia [high triglycerides, low HDL], hypertension, and IFG) is considered sufficient to diagnose the syndrome.1–3 Twenty-four percent of US adults have the MetS and the prevalence increases with age (44% at 60 years of age).4

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