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Endocrine Oncology, Thyroid Disorders
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The Use of Sorafenib in Thyroid Cancer

Published Online: March 25th 2013
Authors: Aneta L Zygulska, Krzysztof Krzemieniecki, Anna Sowa-Staszczak
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Abstract

There are not effective therapies for metastatic unresectable, non-radioactive iodine (RAI)-avid thyroid carcinomas. Fortunately, thyroid carcinomas represent a promising paradigm for targeted therapy due to the presence of activating mutations of genes coding the kinase
tyrosines that are involved in all functions of cancer cells (such as growth or invasion). In this paper, an efficacy and toxicity of sorafenib, one of the multi-kinase inhibitors in thyroid carcinomas treatment, is presented.

Abstract

There are not effective therapies for metastatic unresectable, non-radioactive iodine (RAI)-avid thyroid carcinomas. Fortunately, thyroid carcinomas represent a promising paradigm for targeted therapy due to the presence of activating mutations of genes coding the kinase
tyrosines that are involved in all functions of cancer cells (such as growth or invasion). In this paper, an efficacy and toxicity of sorafenib, one of the multi-kinase inhibitors in thyroid carcinomas treatment, is presented.

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