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Rohit Loomba, EASL ILC 2021: Pemafibrate Phase 2 Results in NAFLD

Published Online: August 12th 2021

We continue our discussion with Prof. Rohit Loomba (University of California, San Diego, CA, USA) by exploring the results for the phase 2 study investigating pemafibrate in NAFLD.

Part 1 of our video interview can be found here.

His presentation entitled ‘Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator (SPPARM alpha), improves liver stiffness by MRE and serum liver and lipid parameters in NAFLD; a randomized, double-blind, placebo-controlled phase 2 trial’ was given at EASL ILC 2021, 23-26 June.

Questions

  1. What were the aims, inclusion criteria and design of your Phase 2 study? (0:18)
  2. What were the key study endpoints and what were the MRI responder criteria? (1:26)
  3. How well were these endpoints met, and what were the safety and tolerability findings? (2:20)
  4. What will be the next stages in the clinical development of pemafibrate in this indication? (4:33)

Disclosures: Prof. Rohit Loomba serves as a consultant for Anylam/Regeneron, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, Bristol-Myer Squibb, CohBar, Eli Lilly, Galmed, Gilead, Glympse Bio, Inipharm, Intercept, Ionis, Janssen Inc., Madrigal, Metacrine, Inc., NGM Biopharmaceuticals, Novartis, Novo Nordisk, Pfizer, Sagimet, 89bio, and Viking Therapeutics. In addition, his institution has received grant support from Allergan, AstraZeneca, Boehringer-Ingelheim, Bristol-Myers Squibb, Eli Lilly, Galectin Therapeutics, Galmed Pharmaceuticals, Genfit, Gilead, Intercept, Inventiva, Janssen, Madrigal Pharmaceuticals, Merck, NGM Biopharmaceuticals, Pfizer and Siemens. He is also a co-founder of Liponexus, Inc.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the EASL ILC 2021, 23-26 June.

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