An Introduction to Endocrine Oncology
Endocrine oncology encompasses malignancies of hormone-producing glands such as the thyroid, parathyroid, pituitary and adrenal gland, as well as endocrine tumours of the gastrointestinal tract and pancreas. While some of these malignancies are relatively rare, thyroid cancer is the most commonly diagnosed cancer in people aged 15–29 years. These cancers present a therapeutic challenge as chemotherapy is often ineffective, and the proliferation rate and the mutational load are usually very low. Advances include small-molecule kinase inhibitors, I-124-positron emission tomography and computed X-ray tomography-based selection of optimal therapeutic strategies, peptide receptor radionuclide therapy with somatostatin receptor antagonists, cell-based therapies and novel immunotherapies.
Browse video highlights and short articles from the conference hub, providing insights into the latest updates from major conferences and peer-reviewed articles from the journal portfolio. This is complemented by a range of educational activities from our expert faculty, with patient outcomes at the forefront.
Endocrine Oncology Content
Panhypopituitarism in a Patient with Burkitt Lymphoma: A Diagnostic and Therapeutic Challenge
touchREVIEWS in Endocrinology. 2024;20(1):Online ahead of journal publication
Burkitt lymphoma (BL) is a non-Hodgkin B-cell lymphoma originating from the germinal center, characterized by dysregulation of the MYC gene, often resulting from the translocation of chromosome 8 into 14. It is extremely aggressive, representing the fastest proliferating cancer, and typically involves the lymph nodes, bone marrow and the central nervous system.1,2 Three identifiable subtypes include sporadic, endemic, […]
Practical considerations for personalized medicine in thyroid cancer: Which therapies are suited to particular patient profiles?
Prof. Brose explores how individual patient profiles underpin personalized medicine in thyroid cancer.
- Identify the different types of thyroid cancer and the recommended methods to test for specific biomarkers
- Evaluate the rationale and latest clinical evidence for current and emerging targeted therapies for thyroid cancer
- Outline the indications, precautions and special considerations related to targeted therapies for personalized thyroid cancer care
Prognostic Biomarkers in Pituitary Tumours: A Systematic Review
touchREVIEWS in Endocrinology. 2023;19(2):42-53
Pituitary tumours (PTs) are located in the sella turcica, which surrounds the adenohypophysis and neurohypophysis. PTs range from asymptomatic incidentalomas to symptomatic aggressive neoplasms, such as invasive neoplasms or pituitary carcinomas.1 Symptomatic lesions can be characterized either by hormonal overproduction or by dysregulation of hormone secretion, and in invasive lesions by tissue destruction and intracranial mass […]
Advancing the management of adult solid tumours in 2023, and beyond: Unlocking the potential of radiopharmaceuticals
Following a scientific primer, the role of radiopharmaceuticals in the management of neuroendocrine tumours and prostate cancer, alongside approaches to support clinical implementation, are explored by leading experts.
- Describe the underlying rationale and mechanism of action for radiopharmaceuticals in adult oncology
- Recall the different types of radiopharmaceuticals (approved and in clinical development), and their specific properties
- Summarize the latest efficacy and safety data available for radiopharmaceuticals in the management of adult solid tumours, including potential implications for current and future clinical practice
- Propose strategies to support integration of radiopharmaceuticals into adult oncology pathways to individualize clinical management, and ultimately, optimize patient outcomes
Sina Jasim, ENDO23: Cytologic and Molecular Assessment of Isthmus Thyroid Nodules
Thyroid nodules arising in the isthmus are more likely to be malignant and demonstrate more aggressive behavior relative to thyroid nodules from either thyroid lobe. touchENDOCRINOLOGY were joined by Dr Sina Jasim (Washington University, St Louis, MO, USA) to discuss the main findings of her study presented at ENDO23. The abstract ‘THU-680 – Cytologic And […]
Surgical Treatment of Solitary Metachronous Adrenal Metastasis from Urothelial Carcinoma of the Urinary Bladder
touchREVIEWS in Endocrinology. 2023;19(1):94-7 DOI: https://doi.org/10.17925/EE.2023.19.1.94
Bladder cancer (BC) is the second most commonly diagnosed urological neoplasm worldwide.1 Approximately 10–15% of patients already have metastases in lymph nodes, lungs, liver and bones at diagnosis.2,3 Metastatic BC has a poor prognosis, with a 5-year overall survival (OS) rate of 10% and median OS of only 15 months.4–6 The vast majority (>90%) of BCs are urothelial […]
Ashley Grossman: Research highlights from 2022 in neuroendocrine tumours
New exciting therapies for neuroendocrine tumours include the introduction of RET inhibitors for medullary thyroid cancer and belzutifan for metastatic pancreatic neuroendocrine tumours. We were delighted to speak with our editorial board member Prof. Ashley Grossman (University of Oxford, Oxford, UK) around this year’s research highlights in these topics and what to look out for […]
Advancing the multidisciplinary management of rare and unusual NETs: Integrating new approaches to treatment and care
Watch leading specialists involved in the multidisciplinary care of patients with rare and unusual neuroendocrine tumours discuss new and emerging approaches for diagnosis and treatment.
- Recognize the role of the MDT in addressing diagnostic and treatment challenges associated with rare and unusual neuroendocrine tumours (NETs)
- Evaluate the factors guiding treatment selection and clinical management decisions in rare and unusual NETs
- Appraise the efficacy and safety of new and emerging treatment options for rare and unusual NETs
A New Medical Therapy for Multiple Endocrine Neoplasia Type 1?
touchREVIEWS in Endocrinology. 2022;18(2):86-8 DOI: https://doi.org/10.17925/EE.2022.18.2.86
Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumour endocrine syndrome, with the parathyroid glands, anterior pituitary gland and pancreas as the main sites of MEN1-related neuroendocrine tumours (NETs). MEN1 is inherited in an autosomal dominant manner, with 90% of individuals diagnosed with this disease having an affected parent, while only 10% have a de […]