Understanding the Immunology of Type 1 Diabetes – An Overview of Current Knowledge and Perspectives for the Future
Type 1 diabetes is classified into two types by the American Diabetes Association; type 1A diabetes is the immune-mediated form and type 1B the non–immune mediated form of the disease, both leading to β-cell destruction and absolute insulin deficiency. It is estimated that approximately 1.5 million people in the US have type 1A diabetes. The […]
The Treatment of Diabetes after an Acute Ischaemic Stroke
Diabetes and ischaemic stroke are common conditions that often co-occur. The relationship between diabetes and stroke is bidirectional.
Fatigue in Adults with Type 2 Diabetes – An Overview of Current Understanding and Management Approaches
Patients with type 2 diabetes commonly experience fatigue, which may be incapacitating and adversely affect self-care regimens.,sup>1–7 Fatigue is a perplexing problem for healthcare providers.8 Wessely suggests that because fatigue is a non-specific and universal symptom, chronic fatigue is challenging to diagnose and treat.9 Fatigue researchers do not have a standardised definition, measurement approach, or […]
AGE, RAGE and Diabetic Nephropathy
Diabetic nephropathy (DN) has become the most frequent cause of terminal renal failure in western countries. Its natural course has been well described and includes the development of functional and structural degenerative changes in the kidney. More specifically, glomerular membrane thickening, mesangial matrix expansion, microvascular changes, arteriolar hyalinosis and tubular degeneration are characteristic aspects of […]
Diabetes and Periodontal Disease
The Relationship Between Periodontitis and Glycaemic Control in Type 2 Diabetes
Periodontitis is a bacteria-related, chronic inflammation that results in destruction of the bone and connective tissue support of teeth forming periodontal pockets between the tooth and gingival soft tissue.1 It is initiated by inadequate oral hygiene and the development of a biofilm colonised with pathogenic bacteria on the tooth surface that results in direct damage […]
Medical Treatment of Cushing’s Disease with Pasireotide
Cushing’s disease is caused by a pituitary adenoma that secretes elevated levels of adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce excess cortisol.1 The tumours are most frequently microadenomas (≤1 cm in diameter) while corticotroph macroadenomas are responsible for approximately 10 % of cases.
Are We Achieving Pharmacological Disease Control in Acromegaly?
Acromegaly is an endocrine disorder and is characterised by soft tissue enlargement and excessive skeletal growth with acral enlargement and coarse facial features. The incidence of acromegaly is approximately 3.3/1,000,000.0/year and the prevalence is 60/1,000,000.1 Although a rare condition, the clinical, economic and health-related quality of life (HRQoL) burden associated with acromegaly is considerable owing […]
Growth Hormone Deficiency During the Transition Phase
The transition period is the span of time in which people complete their somatic and psychological development after reaching their full stature (also known as late teenage years, post-adolescence or young adulthood). It starts in late puberty and comes to an end at around 25 years of age, thus lasting from three to 10 years. […]
Temozolomide in the Treatment of Aggressive Pituitary Tumours – An Overview of Existing Knowledge and Future Perspectives
Pituitary tumours are common, with an estimated prevalence of 16.7 % in the general population based on imaging and autopsy studies.1 Clinically significant pituitary tumours are more prevalent than previously recognised, with one case per 1,000–1,300 people.2,3 The majority of pituitary tumours are indolent, slow-growing neoplasms. However, 40–50 % of pituitary tumours are locally invasive […]
Witnessing a New Era? – The Emerging Role of Targeted Drugs in the Medical Treatment of Advanced Medullary and Anaplastic Thyroid Cancer
Malignancies of the thyroid can be classified as either of follicular cell origin or parafollicular C-cell origin.
Journal articles and more to your inbox
Get the latest clinical insights from touchENDOCRINOLOGYSign me up!