Welcome to the winter edition of US Endocrinology!
This issue features articles that tackle many of the most important issues relevant to endocrinologists, as well as reflecting the progress and challenges in this active area of clinical research. Our popular expert interviews provide concise snapshots of hot topics in medicine. Our editorials focus on the management of hypothyroidism in pediatric patients and the concept of ketocrinology in the management of type 2 diabetes.
The global epidemic of type 2 diabetes continues to be a major focus of clinical research. It been associated with an increased risk of osteoporosis, and bone health is the focus of an original research article. Given the high prevalence of prediabetes, Jeffrey Mechanick presents a new concept of T2D: the Dysglycemia-Based Chronic Disease model. In a fascinating review, Winning and Linden discuss the complicated relationship between diabetes and chronic periodontitis, in which one disease is a co-factor in the pathogenesis of the other.
US Endocrinology would like to thank all expert authors who contributed towards this edition. A special thanks goes to our Editorial Board for their continuing support and guidance. Thanks also go to all organizations and media partners for their ongoing support. We hope that you will find it a useful and informative read.
Foreword – US Endocrinology. 2018;14(2):49
Welcome to the Fall edition of US Endocrinology, which features a series of articles that tackle many of the important issues relevant to endocrinologists, as well as reflecting the progress and challenges in this active area of clinical research. Our popular expert interviews provide concise snapshots of hot topics in medicine. Stephen LaFranchi explores […]
Managing Hypothyroidism in Pediatric Patients
This interview explores current controversies in the management of hypothyroidism in children. Newborn screening programs have allowed early detection and treatment of babies with congenital hypothyroidism, but some programs do not detect cases with delayed thyroid-stimulating hormone (TSH) elevation and most do not detect congenital central hypothyroidism. Lack of harmonization of TSH cut-offs means […]
Latest Developments in Continuous Glucose Monitoring, Insulin, and Adjunctive Treatments in Type 1 Diabetes
Type 1 diabetes (T1D) is a substantial health burden worldwide, with approximately 1.35 million American children and adults living with T1D in 2015.1 Current guidelines from the American Diabetes Association (ADA) recommend an intensive insulin regimen for the treatment of T1D,2 on the basis of long-term clinical evidence.3 While the benefits of insulin are […]
Leonardo da Vinci and the Insulin Experience
The year 2019 is special. It marks the anniversary of two events: one a beginning, the other an end. While the beginning signals an end, the end represents a beginning as well. Both events have influenced humankind immensely; both deserve to be remembered and celebrated. The first event took place 500 years ago, on […]
Ketogenic diet (KD), though over a century old,1 has recently drawn attention to its multifaceted therapeutic potential. Modern use of KD can be traced back to 1911, when French physicians Gulep and Marie reported improvement in seizures in children and adults who were prescribed a fasting regimen.1 Initially used for the management of childhood […]
The Ketogenic Diet
Ketogenic diet (KD) is defined as a high-fat, low-carbohydrate diet, with adequate protein content, which makes the body utilize fat, rather than carbohydrate, as a preferred energy substrate. In a carbohydrate-replete person, this substrate is converted to glucose, which is used as a fuel by all organs, including the brain. In carbohydrate depletion, ketogenesis […]
Underlying Mechanisms Between Diabetes Mellitus and Osteoporosis
Diabetes mellitus has been associated with decreased bone quality and higher risk of fractures in several studies.1–3 Patients with type 1 diabetes have lower bone mineral density and patients with type 2 diabetes have an increased risk of fracture despite normal or high bone mineral density, measured by dual energy x-ray absorptiometry.1,4,5 While some […]
Management Options for Infertile Women with Polycystic Ovary Syndrome
Lifestyle Obesity has a negative impact on the reproductive outcome of women with polycystic ovary syndrome (PCOS). It affects natural conception reducing the chance of spontaneous ovulation, and increases the rate of miscarriage as well as the risk for complications during pregnancy and adverse perinatal outcomes.1–4 Lifestyle modification programs based on a combination of […]
Telemedicine Services for Emerging Adults with Type 1 Diabetes
Emerging adulthood, which encompasses those who are 18–30 years old, has been defined as a period of identity exploration, instability, self-focus, feeling in-between, and a time filled with optimism where anything seems possible.1–4 During this development individuals establish independence, define who they are, and make important educational and vocational choices.1–5 Emerging adults with type […]
Dysglycemia-based Chronic Disease— Diabetes Re-worked
Diabetes afflicts 9.4% of the US population with about 90–95% having type 2 diabetes (T2D) and another 33.9% of the US population having prediabetes (2017 data).1 In 2015, it was estimated that 23.8% of patients with diabetes and 88.4% of patients with prediabetes did not even know they had the condition.1 This diabetes and […]
A Review of the Relationship Between Chronic Periodontitis and Diabetes
Chronic periodontitis (CP; Figure 1) is a multifactorial inflammatory disease associated with dysbiotic dental plaque biofilms and characterized by progressive destruction of the tooth‐supporting structures.1 CP is a major public health problem due to its high prevalence and because it may lead to tooth loss and disability. CP negatively affects chewing function and thereby […]
Bone Health Clinical Practice in India— Concern Regarding Vitamin D Toxicity
Disorders related to bone health are commonly seen in clinical practice in India. The most common conditions are vitamin D deficiency-related disorders (rickets, osteomalacia), followed by osteoporosis, hyperparathyroidism, endocrine osteopathies, and impaired bone health associated with systemic diseases.1–3 Vitamin D deficiency prevalence in India ranges from 70–90% of the population.3,4 Bone disorders are managed […]