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    An Introduction to Reproductive Endocrinology

    Reproductive endocrinology concerns the hormones and control mechanisms that regulate sexual development, function and reproduction. Fertility problems are common issues encountered, which affect about 15% of couples. While outcomes have improved for assisted reproduction, success rates remain low. Advances in epigenomics, genomics, transcriptomics, proteomics and metabolomics are facilitating IVF procedures and identifying oocytes with anomalies, resulting in a higher rate of live births. Molecular biomarkers of fertility problems have also been discovered. New formulations and delivery systems for GnRH analogues, gonadotropins, and sex steroids are further improving fertility outcomes. In terms of menopausal hormone replacement therapy, individualization, dose minimization, and early initiation of therapy, have increased the benefit-risk ratio.

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